Elucidating fundamental principles that govern viral entry, fusion, pathogenicity and restriction
We Have Three Major Research Areas:
Virus-cell and cell-cell fusion
The entry of enveloped viruses, such as influenza A, HIV-1, SARS-CoV, and Ebola virus and others, utilize viral glycoproteins on its surface to mediate cellular attachment, tropism, and viral-host membrane fusion.
Anti-viral immune restriction factors
The human innate immune system has developed complex responses to prevent the spread of pathogens.
Discovery of anti-viral agents
Using our structural models as a molecular blueprint, we aim to develop new therapeutic strategies to combat viruses.Understanding the entry, and immunological restriction of viral pathogens is fundamental for fighting infectious disease.